6.3 Defence against infectious disease

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6.3 Defence against infectious disease



Defence against infectious disease




6.3 Concept mapping

6.3 Knowledge control

6.3 Presentation

6.3 Video /Animation

6.3 Past paper  questions

Essential idea:

6.3.1  The human body has structures and processes that resist the continuous threat of invasion by pathogens.

Immune system game

Immune responses game

Great videos

Nature of science:

6.3.2  Risks associated with scientific research—Florey and Chain’s tests on the safety of penicillin would not be compliant with current protocol on testing. (4.8)




6.3.3  The skin and mucous membranes form a primary defence against pathogens that cause infectious disease.


Play the mosquito game


6.3.4  Cuts in the skin are sealed by blood clotting.

Blood clotting

6.3.5  Clotting factors are released from platelets.

6.3.6  The cascade results in the rapid conversion of fibrinogen to fibrin by


6.3.7  Ingestion of pathogens by phagocytic white blood cells gives non-specific immunity to diseases.


6.3.8  Production of antibodies by lymphocytes in response to particular pathogens gives specific immunity.


http://www.kscience.co.uk/animations/lymphocyte.htm/ Animation of lymphocyte


Animation of phagocyte

The humoral immune system animation

The cellular immune system animation

Cytotoxic T cell Activity Against Target Cells Animation

T cell  Dependent Antigens animations

Monoclonal Antibody Production  


6.3.9  Antibiotics block processes that occur in prokaryotic cells but not in

eukaryotic cells.


6.3.10  Viruses lack a metabolism and cannot therefore be treated with antibiotics.


6.3.11  Some strains of bacteria have evolved with genes that confer resistance to antibiotics and some strains of bacteria have multiple resistance.


Tutorial “The Rise in Antibiotic Resistance”




6.3.12  Application: Causes and consequences of blood clot formation in coronary arteries.


6.3.13   Application: Florey and Chain’s experiments to test penicillin on bacterial infections in mice.


6.3.14   Application: Effects of HIV on the immune system and methods of





6.3.15  Diagrams of skin are not required.


6.3.16  Subgroups of phagocyte and lymphocyte are not required but students

should be aware that some lymphocytes act as memory cells and can quickly

reproduce to form a clone of plasma cells if a pathogen carrying a specific

antigen is re-encountered.


6.3.17   The effects of HIV on the immune system should be limited to a reduction in the number of active lymphocytes and a loss of the ability to produce antibodies, leading to the development of AIDS.

HIV infection 1 

http://www.galaxygoo.org/biochem/hiv/hiv_lifecycle.html/HIV infection 2 http://highered.mcgraw-hill.com/sites/0072556781/student_view0/chapter33/animation_quiz_1.html/

ELISA Test in diagnosishttp://www.sumanasinc.com/webcontent/animations/content/pregtest.html/

ELISA Test in pregnancy testing  




6.3.18  The spread and containment of diseases such as bird flu require international coordination and communication.




6.3.19  An understanding of immunity has led to the development of vaccinations.


6.3.20  Syllabus and cross-curricular links:



Topic 5.2 Natural selection



Topic D2 Aspirin and penicillin




6.3.21  Aim 8: The social as well as the economic benefits of the control of bacterial diseases around the world should be stressed.



6.3.21  Aim 9: Science has limited means in the fight against pathogens, as shown by the spread of new diseases and antibiotic-resistant bacteria.




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