2.7 DNA replication transcription and translation

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2.7 DNA replication transcription and translation

2.7 DNA replication transcription and translation

Concept mapping of the 2.7 DNA Replication, Transcription and Translation

Knowledge control of 2.7 DNA Replication, Transcription and Translation

Essential idea:

2.7.1 Genetic information in DNA can be accurately copied and can be translated to make the proteins needed by the cell.

 

Structural  basis of DNA replication animation 

 

Nature of science:

 

2.7.2 Obtaining evidence for scientific theories—Meselson and Stahl obtained evidence for the semi-conservative replication of DNA. (1.8)

 

DNA Replication 

Bidirectional  DNA Replication animation

How Nucleotides Are Added in DNA Replication

 

 

Understandings:

 

2.7.3 The replication of DNA is semi-conservative and depends on complementary base pairing.

 

DNA Replication 

Interactive DNA replication animation

 

2.7.4  Helicase unwinds the double helix and separates the two strands by breaking hydrogen bonds.

 

 DNA replicaiton animation

 

2.7.5  DNA polymerase links nucleotides together to form a new strand, using the pre-existing strand as a template.

 

DNA Replication of Leading and Lagging Strands 

2.7.6  Transcription is the synthesis of mRNA copied from the DNA base sequences by RNA polymerase.

 

Animation of transcription and translation

The central dogma

Simple gene expression

Transcription and traslation in prokaryotic and eukaryotic cells

Semiconservative replication of DNA

 

2.7.7 Translation is the synthesis of polypeptides on ribosomes.

 

Protein Synthesis

 

2.7.8 The amino acid sequence of polypeptides is determined by mRNA according to the genetic code.

 

2.7.9  Codons of three bases on mRNA correspond to one amino acid in a

polypeptide.

 

2.7.10 Translation depends on complementary base pairing between codons on mRNA and anticodons on tRNA.

 

 

Applications:

 

2.7.11 Application: Use of Taq DNA polymerase to produce multiple copies of DNA

rapidly by the polymerase chain reaction (PCR).

 

2.7.12 Application: Production of human insulin in bacteria as an example of the

universality of the genetic code allowing gene transfer between species.

 

Skills:

 

2.7.13 Skill: Use a table of the genetic code to deduce which codon(s) corresponds  to which amino acid.

 

2.7.14 Skill: Analysis of Meselson and Stahl’s results to obtain support for the theory of semi-conservative replication of DNA.

 

2.7.15 Skill: Use a table of mRNA codons and their corresponding amino acids

to deduce the sequence of amino acids coded by a short mRNA strand of

known base sequence.

 

2.7.16 Skill: Deducing the DNA base sequence for the mRNA strand.

 

Guidance:

 

2.7.17 The different types of DNA polymerase do not need to be distinguished

 

Utilization:

 

2.7.18 Syllabus and cross-curricular links:

Biology

Topic 3.5 Genetic modification and biotechnology

Topic 7.2 Transcription and gene expression

Topic 7.3 Translation

Aims:

2.7.19 Aim 8: There are ethical implications in altering the genome of an organism

in order to produce proteins for medical use in humans.

2.7 DNA Replication, Transcription and Translation Presentation

2.7 DNA Replication, Transcription and Translation Past Paper Questions

2.7 DNA Replication, Transcription and Translation Worksheets

2.7 DNA Replication, Transcription and Translation Animations/Videos




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